5 of the best girls’ weekend getaways in America, according to Reader’s Digest

A weekend away with your closest friends can be the ultimate recharge. Girls’ trips offer more than just a break from routine — they create space for laughter, indulgence, and memory-making. From bustling city streets to quiet mountain retreats, there’s a weekend escape to fit every mood and style. The key is simplicity: leave work, responsibilities, and even your phone notifications behind. What matters most is the experience you share, not the Instagram moment.

Some destinations are built for energy. Live music, buzzing nightlife, and endless dining options turn a city into a playground. Other trips center on relaxation: a spa retreat, a beachside rental, or a cozy cabin in the woods can reset your mind and body. Adventure-minded squads may chase the untouched beauty of national parks, while culturally curious friends might explore historic towns or iconic landmarks. 

America’s weekend destinations are abundant, varied, and often closer than you think. You don’t need to hop on a plane to feel transported, though traveling can add a thrill. Reader’s Digest highlights standout locales across the country, each offering something distinct for women ready to unwind, explore, or simply revel in the company of one another.

Here are five of the top picks for your next girls’ weekend getaways, each bringing a unique flavor of fun, culture, and relaxation.

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Nashville blends country charm with vibrant nightlife, making it ideal for a weekend with friends, according to RD. The city’s bars, honky-tonks, and concert halls provide constant entertainment, whether you’re catching live performances or discovering up-and-coming acts. Iconic sites like the Country Music Hall of Fame and Grand Ole Opry connect visitors to the city’s musical roots. Food is equally compelling: the city’s barbecue joints and modern restaurants, such as The 404 Kitchen, serve bold flavors that perfectly complement a night on the town. For accommodations, Nashville’s West End, including the Hutton Hotel, offers easy access to music venues and dining. The city balances classic Southern warmth with an energetic social scene, giving friends both opportunities to unwind and to celebrate.

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Las Vegas guarantees a high-energy girls’ weekend with its combination of entertainment, nightlife, and luxury accommodations, according to RD. The city’s casinos and shows draw visitors eager to experience glamour, from seeing headline performers to sampling curated cocktails. Dining is diverse and top-tier; restaurants like Joe’s Seafood, Prime Steak & Stone Crab satisfy every palate. Hotels such as the Wynn Las Vegas provide amenities ranging from pools to spas, making it possible to mix relaxation with excitement. Beyond gambling, the city offers unique experiences, ensuring the weekend isn’t limited to casinos.

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New Orleans delivers a sensory-packed weekend full of music, food, and culture. Known as the birthplace of jazz, its nightlife and live music venues provide a rich soundtrack for any girls’ trip, according to RD. Culinary experiences are central: dishes such as shrimp gumbo, crawfish étouffée, and fried-oyster po’ boys showcase the city’s French, Spanish, and African influences. Café Du Monde’s beignets offer a sweet ritual to punctuate any day of exploration. Beyond food and music, the city’s historic neighborhoods and vibrant street life make wandering a rewarding experience. New Orleans balances celebration with cultural depth, creating a weekend that is both indulgent and memorable.

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San Francisco pairs scenic beauty with urban exploration. The Golden Gate Bridge anchors the city’s aesthetic, while neighborhoods like the Mission and Chinatown provide diverse culinary and cultural experiences. Bars and restaurants range from elevated cuisine to casual eateries, ensuring a mix of flavors. Literary-themed accommodations, such as the Emblem Hotel, add character and convenience, with features like nightly jazz and curated cocktails. Pedestrian-friendly streets and distinctive architecture make city walks a pleasure, encouraging friends to explore both landmarks and hidden gems, according to RD. San Francisco provides a balance of activity and relaxation, ideal for groups seeking culture, cuisine, and iconic West Coast charm.

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The Big Apple $AAPL is built for 24/7 exploration, with endless options for dining, entertainment, and sightseeing, says RD. Night owls can enjoy late-night movie screenings, bustling bars, and round-the-clock convenience stores. Early risers have access to famous landmarks, such as the Empire State Building, before crowds arrive. Boutique hotels like the Giraffe Hotel on East 26th Street offer upscale accommodations in the heart of the city, ensuring convenience for sightseeing or nightlife. New York’s diversity and pace make it easy for friends to craft a personalized weekend itinerary, whether focused on culture, shopping, or simply experiencing the city’s energy. The city’s ability to entertain every preference makes it a reliable choice for dynamic weekend getaways.